Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
New article on the simultaneous action of force and confinement on amyloid fibrils is out on Physical Review Letters!
The final version of our article on simulating the action of Hsp70 as unfoldase is finally out on eLife.
New article on cholesteric liquid crystals under confinement just published on Scientific Reports!
Our Review on the soft matter foundations of food macrocomponents is finally out in Nature Reviews Physics! You can access it for free clicking here
New article on enzymatic reactions in lipid-based nanoconfinement published on Angewandte!
Double update today: Our article on amorphous water in nanoconfinement was featured on Chemistry World
New article " Impact of Molecular Partitioning and Partial Equilibration on the Estimation of Diffusion Coefficients from Release Experiments " published on Langmuir!
Very exciting news! Our new article " Soft biomimetic nanoconfinement promotes amorphous water over ice " has just been published on Nature Nanotechnology!
New article " The interplay of channel geometry and molecular features determines diffusion in lipidic cubic phases " is finally out on the Journal of Chemical Physics!
Our article " Curvature and bottlenecks control molecular transport in inverse bicontinuous cubic phases " published in The Journal of Chemical Physics was selected as 2018 Editors' choice !
Research InterestsMy research interests are quite heterogeneous, and span several fields. Click on an image or visit the "Research" tab to find out what I've been working on!
Lipidic mesophases are interesting objects obtained by mixing water and lipids in suitable proportions.
Depending on the specific details of the lipids employed as well as on lipid concentration and temperature,
mesophases with different microscopic structures are obtained, including arrangements as hexagonal, lamellar and cubic phases.
Lipidic mesophases are at the center of intense research due to many different applications,
most of which are based on the molecular transport within these systems.
My research on the topic is focused on understanding the interplay between structure and transport,
with the goal of providing a reliable theoretical framework for devising related applications with tailored properties.
For example, in a paper we have provided the necessary theoretical framework to analyze the results of the so-called diffusion setup. Comparison of the theoretical predictions against experimental data from systems with known features shows an excellent quantitative agreement without any adjustable parameter, thus appointing our theory as a reliable tool for data analysis.
In another work, by combining theory and experiments we showed that polymer diffusion within cubic mesophases can be regulated by as many as three different mechanisms, reminescent of Zimm, Rouse and reptation dynamics.
More recently, we have studied how the nanostructure of cubic phases affects diffusion by Brownian Dynamics simulations. Our results show that the effective diffusion coefficient is regulated by a subtle interplay between curvature and bottlenecks of the network of water channels. Moreover, comparison with experiments enables assessing the amount of immobilized water starting from the theoretical prediction. The results from this study can be used by experimental researchers to estimate the diffusion coefficient of a molecule diffusing within a cubic phase of interest. To ease such application, you can find here a tool that computes the effective diffusion coefficient starting from the structural parameters of the cubic phase.
Lipidic Cubic Phases also provide good environments for enzymatic reactions. For example, we have studied how how the activity of the enzyme aldolase is enhanced when within a cubic phase and, based on the known structure of the enzyme and of mesophases, we suggested a microscopic picture of how such an enhancement can be achieved.
Interplay between confinement and drag forces determine the fate of amyloid fibrils
K. B. Smith, M. Wehrli, A. Japaridze, S. Assenza, C. Dekker and R. Mezzenga
Phys. Rev. Lett. 124, 118102 (2020)
Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones
S. Assenza, A. S. Sassi, R. Kellner, B. Schuler, P. De Los Rios and A. Barducci
eLife 8, e48491 (2019)
Six-fold director field configuration in amyloid nematic and cholesteric phases
M. Bagnani, P. Azzari, S. Assenza and R. Mezzenga
Sci. Rep. 9, 12654 (2019)
Soft condensed matter physics of foods and macronutrients
S. Assenza and R. Mezzenga
Nature Reviews Physics 1, 551 (2019)
(Click here to access it for free)
Spatiotemporal Control of Enzyme‐Induced Crystallization Under Lyotropic Liquid Crystal Nanoconfinement
J. J. Vallooran, S. Assenza and R. Mezzenga
Angew. Chem. Int. Ed. 58, 7289 (2019)
Impact of Molecular Partitioning and Partial Equilibration on the Estimation of Diffusion Coefficients from Release Experiments
R. Ghanbari, S. Assenza*, P. Zueblin and R. Mezzenga
Langmuir 35, 5663 (2019) ( *Co-first author )
Soft biomimetic nanoconfinement promotes amorphous water over ice
L. Salvati Manni, S. Assenza*, M. Duss, J. J. Vallooran, F. Juranyi, S. Jurt, O. Zerbe, E. M. Landau and R. Mezzenga
Nat. Nanotechnology 14, 609 (2019) ( *Co-first author )
The interplay of channel geometry and molecular features determines diffusion in lipidic cubic phases
R. Ghanbari, S. Assenza and R. Mezzenga
J. Chem. Phys. 150, 094901 (2019)
- Confinement‐Induced Ordering and Self‐Folding of Cellulose Nanofibrils
K. B. Smith, J.‐N. Tisserant, S. Assenza, M. Arcari, G. Nyström and R. Mezzenga
Adv. Sci. 6, 1801540 (2019)
- Efficient Asymmetric Synthesis of Carbohydrates by Aldolase Nano-Confined in Lipidic Cubic Mesophases
T. Zhou, J. J. Vallooran, S. Assenza, A. Szekrenyi, P. Clapés and R. Mezzenga
ACS Catal. 8, 5810 (2018)
Curvature and bottlenecks control molecular transport in inverse bicontinuous cubic phases
S. Assenza and R. Mezzenga
J. Chem. Phys. 148,054902 (2018)
Shape of a Stretched Polymer
A. S. Sassi, S. Assenza* and P. De Los Rios
Phys. Rev. Lett. 119, 037801 (2017) ( *Corresponding Author )
Diffusion of Polymers through Periodic Networks of Lipid-Based Nanochannels
R. Ghanbari, S. Assenza*, A. Saha and R. Mezzenga
Langmuir 33,3491 (2017) ( *Co-first author )
Quantifying the transport properties of lipid mesophases by theoretical modelling of diffusion experiments
L. M. Antognini, S. Assenza, C. Speziale and R. Mezzenga
J. Chem. Phys. 145,084903 (2016)
Quantifying the role of chaperones in protein translocation by computational modeling
S. Assenza*, P. De Los Rios and A. Barducci
Front. Mol. Biosci. 2,8 (2015) ( *Corresponding Author )
Universal Behavior in the Mesoscale Properties of Amyloid Fibrils
S. Assenza, J. Adamcik, R. Mezzenga and P. De Los Rios
Phys. Rev. Lett. 113, 268103 (2014)
Emerging Meso- and Macroscales from Synchronization of Adaptive Networks
R. Gutiérrez, A. Amann, S. Assenza, J. Gómez-Gardeñes, V. Latora, and S. Boccaletti
Phys. Rev. Lett. 107, 234103 (2011)
Emergence of structural patterns out of synchronization in networks with competitive interactions
S. Assenza, R. Gutiérrez, J. Gómez-Gardeñes, V. Latora, and S. Boccaletti
Sci. Rep. 1,99 (2011)
Enhancement of cooperation in highly clustered scale-free networks
S. Assenza, J. Gómez-Gardeñes and V. Latora
Phys. Rev. E 78,017101 (2008)
Here you can find some tools I developed to facilitate analysis of experimental results on cubic phases. Click on the title of the tool to use it. The tools can be freely used, and relevant references are listed for each of them. Please cite the appropriate articles if you use the tools in your research!
- Assenza and Mezzenga, J. Chem. Phys. 148:054902 (2018)
- Antognini, Assenza, Speziale and Mezzenga, J. Chem. Phys. 145:084903 (2016)